Persistence of a multidrug-resistant worldwide-disseminated methicillin-resistant Staphylococcus epidermidis clone harbouring the cfr linezolid resistance gene in a French hospital with evidence of interspecies transfer to several Staphylococcus aureus lineages.
Marina Farrel CôrtesCamille AndréPatricia Martins SimõesStéphane CorvecJocelyne CaillonAnne TristanMichèle BesFrançois VandeneschAgnes Marie Sá FigueiredoCéline DupieuxFrédéric LaurentPublished in: The Journal of antimicrobial chemotherapy (2022)
The results presented herein highlight the persistence and efficient spread of a cfr-carrying plasmid in a hospital related both to the dissemination of a multidrug-resistant S. epidermidis clone and the in vivo interspecies transfer of cfr between S. epidermidis and S. aureus. The emergence of linezolid-resistant strains should be closely monitored, and the mechanisms involved systematically explored in order to limit the spread of plasmid-mediated resistance.
Keyphrases
- biofilm formation
- staphylococcus aureus
- multidrug resistant
- escherichia coli
- methicillin resistant staphylococcus aureus
- electron transfer
- drug resistant
- gram negative
- acinetobacter baumannii
- klebsiella pneumoniae
- pseudomonas aeruginosa
- healthcare
- acute care
- crispr cas
- candida albicans
- adverse drug
- copy number
- gene expression
- emergency department
- cystic fibrosis
- dna methylation
- transcription factor
- electronic health record