Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration.

Meng XuJunlan HuangMin JinWanling JiangFengtao LuoQiaoyan TanRuobin ZhangXiaoqing LuoLiang KuangDali ZhangSen LiangHuabing QiHangang ChenZhenhong NiNan SuJing YangXiaolan DuBo ChenChuxia DengYangli XieLin Chen

Published in: Stem cell research & therapy (2022)

NP cells are novel subpopulation of postnatal NP with long-existing proliferative capacity shaping the adult NP structure and participating in the homeostasis maintenance and intrinsic repair of NP. These findings may facilitate the development of new therapeutic approaches for IVD regeneration.

Keyphrases

induced apoptosis
stem cells
cell cycle arrest
preterm infants
oxidative stress
signaling pathway
cell proliferation