Minimal role for the alternative pathway in complement activation by HIT immune complexes.
Ayiesha P BarnesSanjay KhandelwalSimone SartorettoSooho MyoungSamuel J FrancisGrace M LeeLubica RauovaDouglas B CinesJon T SkareCharles E BoothBrandon L GarciaGowthami M ArepallyPublished in: Journal of thrombosis and haemostasis : JTH (2022)
Collectively, these findings suggest the alternative pathway contributes little in support of complement activation by HIT immune complexes. Additional in vitro and in vivo studies are required to examine if this property is shared by most IgG-containing immune complexes or if predominance of the classic pathway is limited to immune complexes composed of multivalent antigens.
Keyphrases