ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy.

Srinivasan AyyanaarChandrasekar BalachandranRangaswamy Chinnabba BhaskarMookkandi Palsamy KesavanSeiji TobitaRamachandran Palpandi RajaJegathalaprathaban RajeshThomas Jay WebsterGurusamy Rajagopal

Published in: International journal of nanomedicine (2020)

In summary, results from the MTT assay, fluorescence staining as well as colony formation assays, revealed that the Fe3O4@OA-CS-5-FLU-NPs were active and safe for anticancer biomedical applications. In summary, the present investigation provides a powerful nanostructured based system for improved cancer theranostics that should be further studied.

Keyphrases

cancer therapy
drug delivery
iron oxide nanoparticles
high throughput
papillary thyroid
drug release
cell death
squamous cell
single cell
dna damage
knee osteoarthritis
single molecule
reactive oxygen species
lymph node metastasis
risk assessment
childhood cancer
oxidative stress
climate change