Acoustic Enrichment of Heterogeneous Circulating Tumor Cells and Clusters from Metastatic Prostate Cancer Patients.
Cecilia MagnussonPer AugustssonEva Undvall AnandAndreas LenshofAndreas JosefssonKarin WelénAnders BjartellYvonne CederHans LiljaThomas LaurellPublished in: Analytical chemistry (2024)
Our preliminary data indicate that acoustophoresis provides excellent possibilities to detect and characterize CTC clusters as a putative marker of metastatic disease and outcomes. Moreover, acoustophoresis enables the sensitive label-free enrichment of cells with epithelial phenotypes in blood and offers opportunities to detect and characterize CTCs undergoing epithelial-to-mesenchymal transitioning and lineage plasticity.
Keyphrases
- circulating tumor cells
- prostate cancer
- label free
- end stage renal disease
- squamous cell carcinoma
- small cell lung cancer
- circulating tumor
- ejection fraction
- chronic kidney disease
- newly diagnosed
- stem cells
- cell cycle arrest
- radical prostatectomy
- electronic health record
- single cell
- peritoneal dialysis
- metabolic syndrome
- big data
- cell death
- machine learning
- signaling pathway
- cell proliferation
- deep learning
- adipose tissue
- weight loss
- artificial intelligence