Genetic regulation of RNA splicing in human pancreatic islets.

Goutham AtlaSilvia Bonàs-GuarchMirabai Cuenca-ArduraAnthony BeucherDaniel J M CrouchJavier Garcia-HurtadoIgnasi Morannull nullManuel IrimiaRashmi B PrasadAnna L GloynLorella MarselliMara SuleimanThierry BerneyEelco J P de KoningJulie Kerr-ConteFrancois PattouJohn A ToddLorenzo PiemontiJorge Ferrer

Published in: Genome biology (2022)

These data expose widespread effects of common genetic variants on RNA splicing in pancreatic islets. The results support a role for splicing variation in diabetes susceptibility, and offer a new set of genetic targets with potential therapeutic benefit.

Keyphrases

genome wide
endothelial cells
type diabetes
cardiovascular disease
electronic health record
glycemic control
nucleic acid
big data
dna methylation
machine learning
gene expression
adipose tissue
weight loss