Our study demonstrates that CRTC1 contribute to the pathological processes of inflammation and apoptosis in sepsis-induced ALI, and provides mechanistic insights into the molecular function of CRTC1 in the lung. Targeting CRTC1 would be a promising strategy to treat sepsis-induced ALI in clinic.
Keyphrases
- signaling pathway
- oxidative stress
- acute kidney injury
- septic shock
- intensive care unit
- diabetic rats
- high glucose
- pi k akt
- cell proliferation
- lipopolysaccharide induced
- epithelial mesenchymal transition
- drug induced
- lps induced
- endoplasmic reticulum stress
- cell death
- drug delivery
- inflammatory response
- single molecule