Regional Selectivity of Neuromelanin Changes in the Substantia Nigra in Atypical Parkinsonism.
Lydia ChougarEmina ArsovicRahul GauravEmma BiondettiAlice FaucherRomain ValabrègueNadya PyatigorskayaGwendoline DupontFrançois-Xavier LejeuneFlorence CormierJean-Christophe CorvolMarie VidailhetBertrand DegosDavid GrabliStéphane LehéricyPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
This study provides the first MRI comparison of the topography of neuromelanin changes in parkinsonism. The spatial pattern of changes differed between PSP and synucleinopathies. These nigral topographical differences are consistent with the topography of the extranigral involvement in parkinsonian syndromes. © 2022 International Parkinson and Movement Disorder Society.