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Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000-2016: a Danish population-based study.

Lasse Hjort Kyneb JakobsenAnne Stidsholt RougAndreas Kiesbye ØvlisenClaus Werenberg MarcherHans Beier OmmenKim Theilgaard-MönchPeter MøllerClaudia SchöllkopfDaniel KristensenTherese Maria Henriette NaurMartin BøgstedTarec Christoffer El-GalalyMarianne Tang Severinsen
Published in: British journal of haematology (2020)
In the present study, we quantify the progress in overall survival (OS) during the period 2000-2016 among Danish patients with acute myeloid leukaemia (AML). This population-based study, including 3820 adult patients with AML, demonstrates a significantly improved OS over time with the 2-year age-standardised OS increasing from 22% in 2002 to 31% in 2016. The improvement in OS was exclusively seen in patients with AML aged ≥50 years, with absolute improvements in 2-year OS from 2002 to 2016 of ≥10% among patients aged 50-75 years and a small absolute increase in those aged >75 years.
Keyphrases
  • acute myeloid leukemia
  • allogeneic hematopoietic stem cell transplantation
  • bone marrow
  • dendritic cells
  • liver failure
  • free survival
  • immune response
  • respiratory failure
  • drug induced
  • aortic dissection