Antimicrobial Testing of Schinus molle (L.) Leaf Extracts and Fractions Followed by GC-MS Investigation of Biological Active Fractions.
Giovanni TurchettiStefania GarzoliValentina Laghezza MasciCarla SabiaRamona IseppiPierluigi GiacomelloAntonio TiezziElisa OvidiPublished in: Molecules (Basel, Switzerland) (2020)
Schinus molle (L.) is a dioecious plant of the Anacardiaceae family, originating in South America and currently widespread in many regions throughout the world. In this work leaf extracts and derived low-pressure column chromatography (LPCC) fractions of S. molle L. male and female plants were investigated for the antimicrobial activity. Leaf extracts were tested on microbes Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Candida albicans and Bacillus subtilis. Furthermore, the extracts showing antimicrobial activity were fractionated by LPCC and the obtained fractions tested on the same microorganism strains. Positive fractions were investigated by gas-chromatography/mass spectrometry (GC-MS) and were seen to be rich in sesquiterpenes, sesquiterpenoids and other terpens. The obtained effects highlighted the antimicrobial properties of S. molle (L.) leaf compounds and revealed their importance as a source of bioactive molecules of potential pharmaceutical interest. To our knowledge, this is the first paper reporting investigations on the chemical composition of the extracts and derived positive fractions from Schinus molle (L.) plants grown in central Italy.
Keyphrases
- staphylococcus aureus
- biofilm formation
- escherichia coli
- candida albicans
- pseudomonas aeruginosa
- gas chromatography mass spectrometry
- bacillus subtilis
- healthcare
- emergency department
- small cell lung cancer
- liquid chromatography
- cystic fibrosis
- risk assessment
- methicillin resistant staphylococcus aureus
- climate change
- high speed
- atomic force microscopy
- adverse drug