A Phenogenetic Axis that Modulates Clinical Manifestation and Predicts Treatment Outcome in Primary Myeloid Neoplasms.
Qiujin ShenYahui FengXiaowen GongYujiao JiaQingyan GaoXiaokang JiaoSaibing QiXueou LiuHui WeiBingqing HuangNingning ZhaoXiaoqiang SongYueshen MaShihao LiangDonglei ZhangLi QinYing WangShiqiang QuYao ZouYumei ChenYe GuoShuhua YiGang AnZengtao JiaoSong ZhangLinfeng LiJun YanHuijun WangZhen SongYingchang MiLugui QiuXiaofan ZhuJian-Xiang WangZhijian XiaoJunren ChenPublished in: Cancer research communications (2022)
The current criteria for disease diagnosis treat myeloid neoplasms as a group of distinct, separate diseases. This work provides genomics evidence for a "myeloid neoplasm continuum" and suggests that boundaries between myeloid neoplastic diseases are much more blurred than previously thought.