PAK and PI3K pathway activation confers resistance to KRAS G12C inhibitor sotorasib.

Chien-Hui ChanLi-Wen ChiouTsai-Yu LeeYun-Ru LiuTsung-Han HsiehChing-Yao Yang Yung-Ming Jeng

Published in: British journal of cancer (2022)

Our results indicate that the cell-matrix interaction-dependent activation of PAK mediates resistance to sotorasib through the activation of MAPK and PI3K pathways.

Keyphrases

oxidative stress
single cell
stem cells
cell therapy
mesenchymal stem cells