Omics Insights into Metabolic Stress and Resilience of Rats in Response to Short-term Fructose Overfeeding.
Kun-Ping LiMin YuanZhuo-Ru HeQi WuChu-Mei ZhangZhi-Li LeiXiang-Lu RongZebo HuangJeremy E TurnbullJiao GuoPublished in: Molecular nutrition & food research (2019)
The findings indicate that SFO disturbs metabolic homeostasis and that endogenous small molecules positively mediate SFO-induced metabolic adaption. The results also underline that an inherent regulatory mechanism of resilience occurs in response to fructose overconsumption, suggesting that efforts to maintain resilience can be a promising target to prevent and treat metabolic disorder-like conditions.