Homozygous mutation of the LRRK2 ROC domain as a novel genetic model of parkinsonism.

Published in: Journal of biomedical science (2022)

This animal provides a novel HOM hLRRK2 R1441G Tg mouse model that reproduces some phenotype of Parkinsonism in terms of both motor and behavioral dysfunction. There is an increased level of mitochondrial fission and no change in the fusion process in the group of HOM hLRRK2 R1441G Tg mouse. This mutant animal model of PD might be used to study the mechanisms of mitochondrial dysfunction and explore potential new drug targets.

Keyphrases

mouse model
drug induced
oxidative stress
parkinson disease
genome wide
gene expression
copy number
risk assessment
emergency department
wild type