MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1.
Enrica VescarelliGiulia GeriniFrancesca MegiorniEleni AnastasiadouPaola PontecorviLuciana SolitoClaudia De VitisSimona CameroClaudia MarchettiRita ManciniPierluigi Benedetti PaniciCarlo DominiciFerdinando RomanoAntonio AngeloniCinzia MarcheseSimona CeccarelliPublished in: Journal of experimental & clinical cancer research : CR (2020)
These data demonstrate that miR-200c significantly enhanced the anti-cancer efficacy of Olaparib in drug-resistant OC cells. Thus, the combination of Olaparib with miRNA-based therapy may represent a promising treatment for drug resistant OC, and our data may help in designing novel precision medicine trials for optimizing the clinical use of PARPi.
Keyphrases
- drug resistant
- multidrug resistant
- induced apoptosis
- acinetobacter baumannii
- cell proliferation
- long non coding rna
- electronic health record
- long noncoding rna
- big data
- cell cycle arrest
- endoplasmic reticulum stress
- oxidative stress
- stem cells
- machine learning
- pseudomonas aeruginosa
- cell death
- artificial intelligence
- pi k akt
- bone marrow
- combination therapy