Downregulation of microRNA-6125 promotes colorectal cancer growth through YTHDF2-dependent recognition of N6-methyladenosine-modified GSK3β.

Hongyan LiNing ZhangXueli JiaoCong WangWenhao SunYanyu HeGanglin RenShirui HuangMengjie LiYixin ChangZihui JinQipeng XieXiaodong ZhangHaishan Huang Honglei Jin

Published in: Clinical and translational medicine (2022)

MiR-6125 regulates YTHDF2 and thus plays a critical role in regulating the Wnt/β-catenin pathway, thereby affecting the growth of CRC. Collectively, these results suggest that miR-6125 and YTHDF2 are potential targets for treatment of CRC.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna

pi k akt
signaling pathway

stem cells
risk assessment

combination therapy
human health