Discriminating Potential Genetic Markers for Complete Response and Non-Complete Response Patients to Neoadjuvant Chemotherapy with Locally Advanced Rectal Cancer.
Jaya BagariaKyung-Ok KimEva BagyinszkySeong Soo A AnJeong-Heum BaekPublished in: International journal of environmental research and public health (2022)
Identifying an array of genes that separate NCRs from CRs would lead to finding genetic biomarkers for early detection of rectal cancer patients that are resistant to nCRT. A further investigation to validate the significance of genetic biomarkers to segregate NCRs from CRs should be performed with a larger CRC dataset. Protein expression levels, as well as transcriptomic analysis, would also help us understand the mechanism of how these genes could play a role in preventing radiation therapy to patients. This would be essential to prevent redundant radiation therapy.
Keyphrases
- locally advanced
- neoadjuvant chemotherapy
- rectal cancer
- radiation therapy
- end stage renal disease
- genome wide
- ejection fraction
- chronic kidney disease
- squamous cell carcinoma
- prognostic factors
- newly diagnosed
- clinical trial
- phase ii study
- dna methylation
- sentinel lymph node
- early stage
- high resolution
- high throughput
- copy number
- patient reported outcomes
- human health
- transcription factor
- climate change