Integrated analysis of DNA methylation profile of HLA-G gene and imaging in coronary heart disease: Pilot study.

Concetta SchianoGiuditta BenincasaTeresa InfanteMonica FranzeseRossana CastaldoCarmela FioritoGelsomina MansuetoVincenzo GrimaldiGiovanni Della ValleGerardo FatoneAndrea SoricelliGiovanni Francesco NicolettiAntonio RuoccoCiro MauroMarco SalvatoreClaudio Napoli

Published in: PloS one (2020)

Reduced levels of circulating HLA-G molecules could derive from epigenetic marks. Epigenetics phenomena induce hypomethylation of specific regions into 5'UTR-CpG island of HLA-G gene in CHD patients with obstructive non critical stenosis vs coronary stenosis individuals.

Keyphrases

dna methylation
genome wide
copy number
gene expression
high resolution
coronary artery disease
genome wide identification
coronary artery
transcription factor
photodynamic therapy
atrial fibrillation
genome wide analysis
aortic stenosis
ejection fraction