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Inflammation in cerebral ischemia reperfusion improved by avanafil via nod-like receptor protein-3 inflammasome: an experimental study in rats.
Huseyin Bekmez
Mehmet Nuri Kocak
Taha Tavaci
Hamza Halici
Erdem Toktay
Muhammet Celik
Hamit Harun Bagci
Published in:
Brain injury (2024)
Avanafil, was found to have ameliorated inflammatory response and cellular injury caused by CI/R. The mRNA expression of IL-1β, NLRP3, and TNF-α decreased in the I/R groups and approached the control group levels with a high dose of avanafil.
Keyphrases
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inflammatory response
high dose
oxidative stress
rheumatoid arthritis
low dose
lipopolysaccharide induced
binding protein
subarachnoid hemorrhage
stem cell transplantation
toll like receptor
protein protein
amino acid
small molecule
cerebral ischemia
immune response
blood brain barrier