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Origin and recent expansion of an endogenous gammaretroviral lineage in domestic and wild canids.

Julia V HaloAmanda L PendletonAbigail S JaroszRobert J GiffordMalika L DayJeffrey M Kidd
Published in: Retrovirology (2019)
Sequence analysis revealed common disruptive mutations, suggesting a predominant form of ERV-Fc spread by trans complementation of defective proviruses. ERV-Fc activity included multiple circulating variants that infected canid ancestors from the last 20 million to within 1.6 million years, with recent bursts of germline invasion in the sublineage leading to wolves and dogs.
Keyphrases
  • single cell
  • copy number
  • cell migration
  • gene expression
  • amino acid
  • genome wide