Association between DNA damage repair gene somatic mutations and immune-related gene expression in ovarian cancer.

Wenjuan TianBoer ShanYuzi ZhangYulan RenShanhui LiangJing ZhaoZhengyi ZhaoGuoqiang WangXiaochen ZhaoDongxian PengRui BiShangli CaiYuezong BaiHua Ying Wang

Published in: Cancer medicine (2020)

DDR deficiency was associated with specific immune signatures in OvCa. Our findings emphasize the urgent need for biomarker-guided rational immune combination therapy to maximize the OvCa patients who could benefit from immunotherapy.

Keyphrases

combination therapy
gene expression
dna damage
copy number
genome wide
dna methylation
oxidative stress
replacement therapy
genome wide identification