WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation.

Lili HaoJing MaFeizhen WuXiaojing MaMaoxiang QianWei ShengTizhen YanNing TangXin JiangBowen ZhangDeyong XiaoYanyan QianJin ZhangNan JiangWenhao ZhouWeicheng ChenDuan MaGuoying Huang

Published in: Clinical and translational medicine (2022)

WDR62 was identified as a novel susceptibility gene for CHD with high variant frequency. WDR62 was shown to participate in the cardiac development by affecting spindle assembly and cell cycle pathway in cardiomyocytes.

Keyphrases

cell cycle
congenital heart disease
copy number
cell proliferation
signaling pathway
left ventricular
genome wide
high glucose
heart failure
gene expression