Direct C( sp )-H/Si-H Cross-Coupling via Copper Salts Photocatalysis.

Reported herein is the first example of C( sp )-H/Si-H cross-coupling by photocatalysis. In terms of cheap and readily available starting materials, a series of alkynylsilanes are prepared in good to excellent yields upon visible-light irradiation of CuCl and alkynes with silane. The large scale reaction with flow chemistry and late-stage functionalization of natural products shows the potential of the transformation in practical organic synthesis of the alkynylsilanes intermediates.