Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain.
Wan-Ci ChenLi-Hsin ChangShiang-Suo HuangYu-Jie HuangChun-Lien ChihHung-Chih KuoYi-Hsuan LeeI-Hui LeePublished in: Journal of neuroinflammation (2019)
Neural cell-specific AHR activation following acute ischemic stroke increased astrogliosis and suppressed neurogenesis in adult mice. AHR inhibition in acute stroke may potentially benefit functional outcomes likely through reducing proinflammatory gliosis and preserving neurogenesis.
Keyphrases
- acute ischemic stroke
- cerebral ischemia
- neural stem cells
- atrial fibrillation
- single cell
- high glucose
- subarachnoid hemorrhage
- diabetic rats
- cell therapy
- blood brain barrier
- brain injury
- drug induced
- type diabetes
- high fat diet induced
- adipose tissue
- metabolic syndrome
- endothelial cells
- mesenchymal stem cells
- insulin resistance