Gestational exposure to triphenyl phosphate induces epigenetic modifications in C57Bl/6 fetal liver.
Sidra ShafiqueSydney H WolpertNicola A PhilbrookLouise M WinnPublished in: Birth defects research (2022)
The results suggest that gestational TPHP exposure can induce epigenetic modifications in murine fetal tissue. Specifically, global DNA methylation levels were downregulated in response to TPHP. Additionally, males appear to be more sensitive to TPHP-induced histone modifications than females. These data support the need for further studies investigating the impacts of gestational TPHP exposure on the developing fetus.
Keyphrases
- dna methylation
- weight gain
- pregnant women
- birth weight
- gene expression
- genome wide
- body mass index
- pregnancy outcomes
- high glucose
- weight loss
- diabetic rats
- electronic health record
- copy number
- big data
- drug induced
- endothelial cells
- machine learning
- oxidative stress
- case control
- gestational age
- artificial intelligence