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Current Challenges and Emerging Therapies in the Treatment of Gout.

Shanthini SivaprakasamJawahar NatarajanJigyasa SinghMonisha Rajesh
Published in: Current rheumatology reviews (2024)
Gout is a common form of inflammatory arthritis characterized by the deposition of MSU in the joints and surrounding tissues, which results in inflammation and recurrent painful attacks. Currently, xanthine oxidase inhibitors, i.e., Allopurinol and Febuxostat, are used in the therapy. Recently, nanoparticles (NPs) containing metal oxides and non-metal oxides have also been developed to better manage gout. This comprehensive review summarizes the pathophysiology of gout, currently used drugs in the treatment, followed by emerging therapies for gout.
Keyphrases
  • uric acid
  • metabolic syndrome
  • oxidative stress
  • rheumatoid arthritis
  • gene expression
  • stem cells
  • cell therapy