Metabolomic Signatures Associated With Pulmonary Arterial Hypertension Outcomes.
Hongyang PiLu XiaDavid D RalphSamuel G RaynerAli ShojaiePeter J LearySina A GharibPublished in: Circulation research (2023)
Distinct plasma metabolomic profiles are associated with RV dilation, mortality, and measures of disease severity in PAH. Polyamine, histidine, and sphingomyelin metabolic pathways represent promising candidates for identifying patients at high risk for poor outcomes and investigation into their roles as markers or mediators of disease progression and RV adaptation.
Keyphrases
- pulmonary arterial hypertension
- mycobacterium tuberculosis
- end stage renal disease
- pulmonary artery
- pulmonary hypertension
- newly diagnosed
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- type diabetes
- cardiovascular events
- cardiovascular disease
- gene expression
- coronary artery disease
- patient reported outcomes
- coronary artery
- adipose tissue
- patient reported
- polycyclic aromatic hydrocarbons
- skeletal muscle
- glycemic control