Effect of Gegen Qinlian Decoction on Hepatic Gluconeogenesis in ZDF Rats with Type 2 Diabetes Mellitus Based on the Farnesol X Receptor/Ceramide Signaling Pathway Regulating Mitochondrial Metabolism and Endoplasmic Reticulum Stress.

Qi Zhou Ning Song Shi-Qi Wang Yan Wang Yi-Kun Zhao Xiang-Dong Zhu

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

GQD can inhibit the FXR/ceramide signaling pathway, regulate endoplasmic reticulum stress, enhance the CS activity of liver mitochondria, reduce the acetyl CoA level and PC activity of liver mitochondria, inhibit hepatic gluconeogenesis, protect islet β-cells, and control blood glucose.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
blood glucose
signaling pathway
oxidative stress
cell death
pi k akt
glycemic control
reactive oxygen species
epithelial mesenchymal transition
endoplasmic reticulum
candida albicans
blood pressure
type diabetes
adipose tissue
insulin resistance
binding protein