Perioperative changes in serum CA125 levels: a prognostic factor for disease-specific survival in patients with ovarian cancer.
Nienke ZwakmanRafli van de LaarToon Van GorpPetra L M ZusterzeelMarc P M L SnijdersIsabel FerreiraLeon F A G MassugerRoy F P M KruitwagenPublished in: Journal of gynecologic oncology (2016)
The current study, although hampered by possible biases, suggests that the perioperative decline in serum CA125 is an early biomarker that predicts disease-specific survival in patients who underwent primary cytoreductive surgery for advanced stage EOC. If confirmed prospectively, the perioperative change in serum CA125 could be a better marker for residual tumor volume after primary cytoreductive surgery (and therewith disease-specific survival) than the surgeons' estimation of residual tumor volume.