Multiple Organ Failure Associated with SARS-CoV-2 Infection in a Child with Down Syndrome: Is Trisomy 21 Associated with an Unfavourable Clinical Course?

Perla Idalia Vazquez-HernándezAlan Cárdenas-ConejoManuel Alejandro Catalán-RuizKarla Navar-GallegosEmilio Zenteno-SalazarJose Rafael-Parra-BravoRanferi Aragon-NogalesMaribel Ibarra-SarlatJuan Carlos Nuñez-Enriquez

Published in: Case reports in pediatrics (2021)

Multiple organ failure observed in the patient presented could be related to the triple gene dose of four interferon receptors (IFNAR1, IFNAR2, IFNGR2, and IL10RB) located at 21q22.11. Additionally, overexpression of TMPRSS2 at the pulmonary level, located also at 21q22.3, could be related with an increased susceptibility for the development of SARS-CoV-2 infection in DS patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
pulmonary hypertension
mental health
prognostic factors
cell proliferation
respiratory syndrome coronavirus
case report
dendritic cells
sars cov
genome wide
transcription factor
copy number
gene expression
immune response