Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway.

Zelin HouFengchun LuJiajing LinYuwei WuLinjin ChenHaizong FangLinlin ChenShihan ZhangHeguang HuangYu Pan

Published in: Journal for immunotherapy of cancer (2024)

This research uncovers a novel role of macrophage ANXA1 in pancreatic cancer. ANXA1-mediated regulation of efferocytosis by tumor-associated macrophages promotes antitumor immune response via STING signaling, suggesting potential treatment strategies for pancreatic cancer.

Keyphrases

immune response
stem cells
adipose tissue
toll like receptor
risk assessment
inflammatory response