Aspermeroterpenes A-C: Three Meroterpenoids from the Marine-Derived Fungus Aspergillus terreus GZU-31-1.
Yuqian TangYena LiuQingfeng RuanMin ZhaoZhongxiang ZhaoHui CuiPublished in: Organic letters (2020)
Aspermeroterpene A (1) with an unprecedented and highly congested 5/3/6/6/6/5 hexacyclic skeleton, together with two precursors aspermeroterpenes B (2) and C (3), were isolated from the marine-derived fungus Aspergillus terreus GZU-31-1. Their structures were elucidated by quantum chemical calculations, X-ray diffraction, and spectroscopic methods. The biogenetic pathway for 1-3 is proposed. Aspermeroterpenes A-C (1-3) showed significant inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells compared to positive control.
Keyphrases
- lps induced
- inflammatory response
- nitric oxide
- molecular dynamics
- induced apoptosis
- high resolution
- cell cycle arrest
- molecular docking
- density functional theory
- toll like receptor
- molecular dynamics simulations
- monte carlo
- hydrogen peroxide
- cell death
- oxidative stress
- nitric oxide synthase
- endoplasmic reticulum stress
- magnetic resonance imaging
- immune response
- signaling pathway
- crystal structure
- computed tomography
- dual energy
- pi k akt