Calling long distance: Cell cycle-dependent Ca2+ flows connect stem cells across regeneration tissues.
Gladiola Goranci-BuzhalaCarien M NiessenPublished in: The Journal of cell biology (2023)
How adult stem cells signal in vivo over time to coordinate their fate and behavior across self-renewing tissues remains a challenging question. In this issue, Moore et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202302095) combine high-resolution live imaging in mice with machine learning tools to reveal temporally regulated tissue-scale patterns of Ca2+ signaling orchestrated by cycling basal stem cells of the skin epidermis.
Keyphrases
- stem cells
- cell cycle
- high resolution
- cell therapy
- machine learning
- single cell
- cell proliferation
- gene expression
- mass spectrometry
- dna methylation
- soft tissue
- type diabetes
- artificial intelligence
- metabolic syndrome
- high intensity
- adipose tissue
- insulin resistance
- tandem mass spectrometry
- deep learning
- high fat diet induced