Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model.

Han ShenGuanghao CuiYanqiong LiWenxue YeYimin SunZihan ZhangJingjing LiGuiying XuXiansheng ZengYanxia ZhangWencheng ZhangZan HuangWeiqian ChenZhenya Shen

Published in: Stem cell research & therapy (2019)

Our results suggest Fstl1 is an intrinsic cardiokine promoting survival and proliferation of MSCs, thereby optimizing their engraftment and therapeutic efficacy during cell therapy.

Keyphrases

cell therapy
mesenchymal stem cells
stem cells
bone marrow
umbilical cord
heart failure
signaling pathway
left ventricular
oxidative stress
free survival
hematopoietic stem cell
atrial fibrillation