Combination of Trastuzumab Emtansine and Stereotactic Radiosurgery Results in High Rates of Clinically Significant Radionecrosis and Dysregulation of Aquaporin-4.
Priscilla K StumpfDiana M CittellyTyler P RobinJulie A CarlsonKelly A StuhrMaria Jose Contreras-ZarateSteven LaiD Ryan OrmondChad G RusthovenLaurie E GasparRachel RabinovitchBrian D KavanaghArthur LiuJennifer R DiamondPeter KabosChristine M FisherPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
The strong correlation between development of CSRN after SRS and T-DM1 warrants prospective studies controlling for variations in timing of T-DM1 and radiation dosing to further stratify risk of CSRN and mitigate toxicity. Until such studies are completed, we advise caution in the combination of SRS and T-DM1.