Behavioural deficits of autism spectrum disorder and associations with different gene clusters: a study with the whole-genome transmission disequilibrium test.

Qi GuoLu XiaRuolan Guo Xiaochen BoYue ZhangChunlin ZhaoPeng ZhangTing BaiXin NiChanjuan HaoKun XiaWei Li

Published in: BMJ paediatrics open (2023)

Whole-genome TDT test is a unique tool in clustering genes related to ASD subtypes of behavioural deficits. Several new candidate genes for ASD are revealed by pathway analysis of the clustered genes. These findings are useful for understanding the underlying mechanism of ASD.

Keyphrases

autism spectrum disorder
genome wide
genome wide identification
attention deficit hyperactivity disorder
intellectual disability
traumatic brain injury
genome wide analysis
bioinformatics analysis
dna methylation
single cell
rna seq
drug induced