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Predictors of reproductive and non-reproductive outcomes of gonadotropin mediated pubertal induction in male patients with congenital hypogonadotropic hypogonadism (CHH).

Biagio CangianoG GoggiS FedericiC BresestiL CotellessaF GuizzardiV VezzoliP DuminucoLuca PersaniMarco Bonomi
Published in: Journal of endocrinological investigation (2021)
This study shows that a strong genetic background and cryptorchidism, as indicators of a complete GnRH deficiency since intrauterine life, are negative predictors of testicular response to gonadotropin stimulation in CHH. Body disproportion is associated with a delay in treatment and duration of growth during the induction, which is apparently inversely related to previous androgenization.
Keyphrases
  • replacement therapy
  • genome wide
  • gene expression
  • combination therapy
  • dna methylation
  • skeletal muscle
  • weight loss