Sex-Dependent Analysis of Temozolomide-Induced Myelosuppression and Effects on Survival in a Large Real-life Cohort of Patients With Glioma.

Pia S Zeiner Katharina FilipskiNatalie FilmannMarie-Thérèse ForsterMartin VossEmmanouil FokasUlrich HerrlingerPatrick N HarterJoachim P SteinbachMichael W Ronellenfitsch

Published in: Neurology (2022)

This study provides Class II evidence that women with glioma treated with temozolomide-based concomitant radiochemotherapy have more frequent treatment-induced severe cytopenia than men and that severe myelosuppression correlates with worse OS in women.

Keyphrases

high glucose
drug induced
diabetic rats
early onset
newly diagnosed
polycystic ovary syndrome
endothelial cells
oxidative stress
squamous cell carcinoma
type diabetes
radiation therapy
metabolic syndrome
middle aged
skeletal muscle
cervical cancer screening