Cobalt-Catalyzed Cross-Coupling of Functionalized Alkylzinc Reagents with (Hetero)Aryl Halides.
Ferdinand H LutterLucie GrokenbergerPhilipp SpießJeffrey M HammannKonstantin KaraghiosoffPaul KnochelPublished in: Angewandte Chemie (International ed. in English) (2020)
A combination of 10 % CoCl2 and 20 % 2,2'-bipyridine ligands enables cross-coupling of functionalized primary and secondary alkylzinc reagents with various (hetero)aryl halides. Couplings with 1,3- and 1,4-substituted cycloalkylzinc reagents proceeded diastereoselectively leading to functionalized heterocycles with high diastereoselectivities of up to 98:2. Furthermore, alkynyl bromides react with primary and secondary alkylzinc reagents providing the alkylated alkynes.