TGF-β1 mediates pathologic changes of secondary lymphedema by promoting fibrosis and inflammation.

Jung Eun BaikHyeung Ju ParkRaghu P KataruIra L SavetskyCatherine L LyJinyeon ShinElizabeth M EncarnacionMichele R CavaliMark G KlangElyn RiedelMichelle CoriddiJoseph H DayanBabak J Mehrara

Published in: Clinical and translational medicine (2022)

Our results show that TGF-β1 is an essential regulator of ECM deposition in secondary lymphedema and that inhibition of this response is a promising means of treating lymphedema.

Keyphrases

transforming growth factor
oxidative stress
neoadjuvant chemotherapy
transcription factor
epithelial mesenchymal transition
locally advanced
extracellular matrix