Influence of the amino-terminal sequence on the structure and function of HIV integrase.

Grant EilersKushol GuptaAudrey AllenJeffrey ZhouYoung HwangMichael B CoryFrederic D BushmanGregory Van Duyne

Published in: Retrovirology (2020)

The structural, biochemical, and biophysical characterization of IN 1F reveals the conformation of the native HIV-1 IN N-terminus and accompanying unique biochemical and biophysical properties. IN 1F thus represents an improved reagent for use in integration reactions in vitro and the development of antiretroviral agents.

Keyphrases

hiv positive
hiv infected
antiretroviral therapy
human immunodeficiency virus
hiv aids
hiv testing
men who have sex with men
hepatitis c virus
hiv infected patients
south africa
crystal structure