In vitro-irradiated cancer vaccine enhances anti-tumor efficacy of radiotherapy and PD-L1 blockade in a syngeneic murine breast cancer model.
Yoomin KimSeung Hyuck JeonSeongmin KimMi Hyun KangMin Guk HanSe Yup LeeIn Ah KimPublished in: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2024)
The ICV enhanced the therapeutic efficacy of local RT and PD-L1 blockade by augmenting anti-tumor immune responses. Our findings suggest a therapeutic potential of in vitro-irradiation products of tumor cells.