Association of variants in the ATXN2 (rs7137828), FOXC1 (rs2745572) and TXNRD2 (rs35934224) genes as risk factors for primary open-angle glaucoma development in a Brazilian cohort.

Thiago Adalton Rosa RodriguesBruno Batista de SouzaVictor de Haidar E BertozzoJúlia Nicoliello Pereira de CastroAna Carolina Lima CamargoFernando Ferreira CostaRui Barroso SchimitiVital Paulino CostaFernanda Maria Silveira Souto Mônica Barbosa de Melo

Published in: Ophthalmic genetics (2023)

Our data indicate the rs7137828 associated with increased risk for the development of POAG and VCDR in a Brazilian cohort. If validated in additional populations, these findings may enable the development of relevant strategies for early diagnosis of glaucoma in the future.

Keyphrases

gene expression
copy number
big data
transcription factor
dna methylation