Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer.
Mohammad Aarif SiddiquiParadesi Naidu GollavilliVignesh RameshBeatrice ParmaAnnemarie SchwabMaria Eleni VazakidouRamakrishnan NatesanOzge SaatciIda RapaPaolo BironzoHarald SchuhwerkIrfan Ahmed AsanganiOzgur SahinMarco VolantePaolo CeppiPublished in: British journal of cancer (2020)
These results establish TS as a theranostic NSCLC marker integrating survival, chemo-resistance and EMT, and identifies a regulatory network that could be targeted in EMT-driven NSCLC.
Keyphrases
- small cell lung cancer
- epithelial mesenchymal transition
- photodynamic therapy
- advanced non small cell lung cancer
- cancer therapy
- brain metastases
- genome wide
- transcription factor
- fluorescence imaging
- locally advanced
- epidermal growth factor receptor
- signaling pathway
- drug delivery
- combination therapy
- squamous cell carcinoma
- dna methylation
- radiation therapy
- rectal cancer
- network analysis