The phenylephrine concentration-response relationship for blood pressure after nasal delivery in children.

Brian Joseph AndersonLisa K ChristensenValerie E ArmsteadDavid P BilyeuKenneth E JohnsonRobert H Friesen

Published in: Paediatric anaesthesia (2017)

Absorption of phenylephrine through the nasal mucosa was rapid and similar to the ophthalmic formulation. Bioavailability was also similar to the ophthalmic formulation. The maximum effect (EMAX ) in children was half that in adults (EMAX 50 mm Hg).

Keyphrases

blood pressure
young adults
drug delivery
chronic rhinosinusitis
type diabetes
metabolic syndrome
adipose tissue
fluorescent probe
sensitive detection