Role of angiopoietin-2 in venous thrombus resolution and chronic thromboembolic disease.

Lukas HobohmSebastian KölmelCaroline NiemannPhilipp KümpersValentin J KriegMagdalena L BochenekAlexander H LukaszYvonne ReissKarl-Heinz PlateChristoph LiebetrauChristoph B WiedenrothStefan GuthThomas MünzelGerd HasenfussPhilip WenzelEckhard MayerStavros V KonstantinidesKatrin SchäferMareike Lankeit

Published in: The European respiratory journal (2021)

Our findings suggest that ANGPT2 delays venous thrombus resolution and that overexpression of ANGPT2 contributes to thrombofibrosis and may thus support the transition from pulmonary embolism to CTEPH.

Keyphrases

pulmonary embolism
inferior vena cava
single molecule
cell proliferation
atrial fibrillation
transcription factor
drug induced