Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis.
Jiao LiuZi-Yi LiuYan FuYu-Cheng GuSong-Wei LiHai-Yan ZhangYue-Wei GuoPublished in: Chemistry & biodiversity (2024)
One new highly degraded steroid, namely 21-nor-4-ene-chaxine A (1) furnishing a 5/6/5-tricyclic, along with one known related analogue (2), were isolated from the South China Sea sponge Spongia officinalis. Their structures including absolute configurations were established by extensive spectroscopic data analysis, TDDFT-ECD calculation, and comparison with the spectral data previously reported in the literature. Compound 1 represent the new member of incisterols family with a highly degradation in ring B. In vitro bioassays revealed compound 2 exhibited significant anti-microglial inflammatory effect on lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells.
Keyphrases
- lps induced
- data analysis
- inflammatory response
- oxidative stress
- induced apoptosis
- anti inflammatory
- lipopolysaccharide induced
- cell cycle arrest
- systematic review
- molecular docking
- essential oil
- optical coherence tomography
- toll like receptor
- high resolution
- electronic health record
- single cell
- endoplasmic reticulum stress
- signaling pathway
- magnetic resonance imaging
- cell death
- immune response
- machine learning
- mass spectrometry
- monte carlo
- molecular dynamics simulations