NLRP3 inflammasome of renal tubular epithelial cells induces kidney injury in acute hemolytic transfusion reactions.

Zhixin LiuYaozhen ChenBing NiuDandan YinFan FengShunli GuQunxing AnJinmei XuNing AnJing ZhangJing YiWen YinXiangyang QinXingbin Hu

Published in: Clinical and translational medicine (2022)

Hemes could activate NLRP3 inflammasome in RTECs, and a novel NLRP3 inflammasome inhibitor named 66PR relieved kidney function damage in AHTR. Our findings provided a new possible strategy to treat kidney function failure in AHTR.

Keyphrases

nlrp inflammasome
liver failure
cardiac surgery
respiratory failure
intensive care unit
aortic dissection
sickle cell disease
endothelial cells
extracorporeal membrane oxygenation