Comparison of inhaled mannitol/dornase alfa combination and daily dornase alfa alone in children with cystic fibrosis.

Dilber Ademhan TuralEbru YalçınNagehan Emiralioğlu Beste Özsezen Birce Sunman Halime Nayir BuyuksahinIsmail GuzelkasDeniz Dogru ErsozUgur OzcelikNural Kiper

Published in: Pediatric pulmonology (2021)

This study showed that in those patients who tolerated long-term (12 months) treatment with DPI mannitol and dornase alfa made greater improvements in FEV1, FVC, FEV1/FVC, FEF25-75 z-scores than treatment with dornase alfa alone in children with CF.

Keyphrases

replacement therapy
cystic fibrosis
young adults
smoking cessation
clinical evaluation