Establishment of a rat ovarian peritoneal metastasis model to study pressurized intraperitoneal aerosol chemotherapy (PIPAC).

Leen Van de SandeWouter WillaertSarah CosynsKaat De ClercqMolood ShariatiKatrien RemautWim Ceelen

Published in: BMC cancer (2019)

we propose a reproducible and efficient rodent model to study PIPAC and ePIPAC in OC xenografts with widespread PM. This model allows to characterize and optimize pharmacokinetic and biophysical parameters, and to evaluate the anti-cancer efficacy of (e)PIPAC treatment.

Keyphrases

oxidative stress
air pollution
particulate matter
squamous cell carcinoma
risk assessment
locally advanced
heavy metals
rectal cancer
smoking cessation